Levitra is administered orally for the treatment of ED – pillsformedicine
Levitra (Vardenafil) is a member of a family of drugs called PDE5 Inhibitors.
Maximum Dose of This Pill :
The maximum dose is one pill per day. The usual starting dose of Levitra is 10mg once per day (60 minutes prior to sexual activity). The dose can be titrated up to 20mg or down to 2.5mg based on efficacy and side effects. This drug can be taken without regard to food.
How Does it Work (Mechanism Of Action) :
When an erection goes flaccid, you have PDE5 to thank. Specialized penis tissue secretes a substance called cyclic guanosine monophosphate (cGMP) in response to sexual stimulation. The more cGMP available, the more durable the erection. This drug inhibits the PDE5 enzyme, preserving cGMP levels, therefore aiding erection viability and durability.
This medicine is indicated for the treatment of erectile dysfunction in adult males (inability to achieve or maintain penile erection sufficient for satisfactory sexual performance).It is not indicated for use by women.
Vardenafil is contraindicated in patients with known hypersensitivity to any of the drug’s components (active or inactive ingredients).Nitrates and vardenafil must not be used concomitantly. Co-administration of vardenafil with nitric oxide donors, organic nitrates, or organic nitrites in any form either regularly or intermittently is contraindicated.Drugs which must not be used concomitantly include, but are not limited to, glyceryl trinitrate (injection, tablets, sprays or patches), isosorbide salts, sodium nitroprusside, amyl nitrite, nicorandil or organic nitrates in any form. Consistent with the effects of PDE inhibition on the nitric oxide / cGMP – pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates.Vardenafil is contraindicated in men for whom sexual intercourse is inadvisable due to cardiovascular risk factors. The possibility of undiagnosed cardiovascular disorders in men with erectile dysfunction should be considered before prescribing this drug .The safety of this medicine has not been studied in patients with the following conditions and its use in such patients is therefore contraindicated until further information is available: unstable angina; resting or orthostatic hypotension (systolic blood pressure <90 mmHg); uncontrolled hypertension; myocardial infarction, stroke, cardiac ischaemia (except stable angina), or life-threatening arrhythmia within the previous 6 months; uncontrolled arrhythmia; severe hepatic impairment; end-stage renal disease requiring dialysis; known hereditary degenerative retinal disorders such as retinitis pigmentosa.
This product has not been administered to patients with bleeding disorders or significant active peptic ulceration. Therefore it should be given to these patients only after careful benefit-risk assessment. In humans, this drug has no effect on bleeding time alone or with aspirin. In vitro studies with human platelets indicate that this pill alone did not inhibit platelet aggregation induced by a variety of platelet agonists. With supertherapeutic concentrations of vardenafil a small concentration-dependent enhancement of the antiaggregatory effect of sodium nitroprusside, a nitric oxide donor, was observed.
Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.
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